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Chronic pain Clinical Trials
Studies with U.S. locations that are recruiting, about to recruit or enrolling by invitation
Study listings come from ClinicalTrials.gov, where sponsors register and update their own studies. A listing does not mean a study is safe or effective, and DatenUS does not recommend any study. Talk with your doctor before joining a clinical trial, and use ClinicalTrials.gov for contact details and full eligibility rules.
- Open studies
- 232
- With at least one U.S. site
- States with a site
- 46
- Most studies
- California
- 41 studies
Recently updated studies
50 of 232, recruiting studies first. Choose a state to see studies near you.
- A Study of Cebranopadol for Opioid Withdrawal Symptoms in Adults With Chronic PainRecruitingPhase 2NCT07874620· Adneuris Therapeutics, Inc.
2 U.S. sites in 2 states
- Evaluation of the PACE/PACENET BHL Clinical ProgramRecruitingNCT02463266· University of Pennsylvania
1 U.S. site in 1 state
- Feasibility and Effects of Noninvasive Brain Stimulation on Pain Perception in People With FibromyalgiaRecruitingNCT07644221· Pulkit Grover
2 U.S. sites in 1 state
- Personalized Analgesia Through Central Nervous System Engagement to Unlock PerformanceRecruitingPhase 4NCT07759336· Benedict Alter
1 U.S. site in 1 state
- Cannabidiol in Opioid Use Disorder and Chronic Pain With BuprenorphineRecruitingEarly Phase 1NCT07886606· Yale University
1 U.S. site in 1 state
- Overlapping Pain Trajectory StudyRecruitingNCT05752396· Children's Hospital Medical Center, Cincinnati
1 U.S. site in 1 state
- Reducing Chronic Pain Following Cesarean DeliveryRecruitingNCT07799883· Stanford University
1 U.S. site in 1 state
- Biopsychosocial Risk Influences on the Development and Generation of Early-Onset Chronic PainRecruitingNCT07602595· Children's Hospital Medical Center, Cincinnati
1 U.S. site in 1 state
- Options for Pain Management Using Nonpharmacological StrategiesRecruitingNCT05563792· VA Office of Research and Development
1 U.S. site in 1 state
- Culturally Adapted Pain Management for Indigenous PeoplesRecruitingNCT07524751· University of California, San Diego
1 U.S. site in 1 state
- RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for PainRecruitingNCT01719055· Boston Scientific Corporation
67 U.S. sites in 25 states
- EPPIC: Easing Pelvic Pain Interventions Clinical Research ProgramRecruitingNCT05127616· State University of New York at Buffalo
3 U.S. sites in 3 states
- Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current ControlRecruitingNCT07190807· Boston Scientific Corporation
7 U.S. sites in 7 states
- Patient Retrospective Outcomes (PRO)RecruitingNCT01550575· Boston Scientific Corporation
87 U.S. sites in 30 states
- Tai Chi Intervention for Geriatric Pain SyndromeRecruitingNCT03705598· University of Massachusetts, Boston
1 U.S. site in 1 state
- Insula Neuromodulation for Chronic Neuropathic PainRecruitingNCT05404581· University of Virginia
1 U.S. site in 1 state
- Safety and Efficacy of Mesenchymal Stem Cells Associated With Chronic Pancreatitis PainRecruitingEarly Phase 1NCT06205342· Medical University of South Carolina
1 U.S. site in 1 state
- Scrambler Therapy in Chronic PancreatitisRecruitingNCT07174609· Johns Hopkins University
1 U.S. site in 1 state
- Chronic Postsurgical PainRecruitingNCT05764681· Chantel Burkitt
2 U.S. sites in 2 states
- Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy PatientsRecruitingNCT06094257· Weill Medical College of Cornell University
2 U.S. sites in 2 states
- Remote Monitoring Using a Digital PlatformRecruitingNCT07837102· Hackensack Meridian Health
2 U.S. sites in 1 state
- Multisite Advancement of Research on Chronic Posttraumatic HeadacheRecruitingNCT05620719· The University of Texas Health Science Center at San Antonio
8 U.S. sites in 5 states
- Brief Mindfulness Intervention for Pain Before an In-clinic Orthopedic ProcedureRecruitingNCT06471075· Florida State University
1 U.S. site in 1 state
- Opioid and Pain Treatment in Indigenous Communities (OPTIC) TrialRecruitingNCT06565416· University of New Mexico
3 U.S. sites in 3 states
- ARPA-H Smart Band-Aid to Measure Chronic Pain in WomenRecruitingNCT06994988· Northwestern University
2 U.S. sites in 2 states
- QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory TestingRecruitingNCT03434392· Anna Evans Phillips
2 U.S. sites in 2 states
- Chronic Widespread Pain in HIV: Novel Mechanisms and TherapeuticsRecruitingNCT04787848· Florida International University
1 U.S. site in 1 state
- Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic PancreatitisRecruitingNCT04996628· University of Pittsburgh
3 U.S. sites in 3 states
- Evaluate the Impact of Targeted Physical Activity on Clinically Debilitated Dialysis Patients.RecruitingNCT06374537· University of Illinois at Chicago
1 U.S. site in 1 state
- A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back PainRecruitingPhase 2NCT07641504· Eli Lilly and Company
36 U.S. sites in 18 states
- A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis PainRecruitingPhase 2NCT07641517· Eli Lilly and Company
36 U.S. sites in 18 states
- The Teaspoon Study - Telefitting Spinal Cord Stimulation for PainRecruitingNCT05741788· University of Minnesota
1 U.S. site in 1 state
- Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Cancer: A Randomized Clinical TrialRecruitingNCT07160621· St. Jude Children's Research Hospital
1 U.S. site in 1 state
- Post Market Evaluation of Real World Outcomes and Durability to Support Implantable Inceptiv™ Spinal Cord Stimulation TherapyRecruitingNCT07507422· Medtronic
5 U.S. sites in 4 states
- Group-Based Psychological Treatments Over Video Conference for Older Veterans With Chronic PainRecruitingNCT06004804· VA Office of Research and Development
2 U.S. sites in 2 states
- NonNarcotic Pain Control in Percutaneous Needle Tenotomy of ElbowRecruitingPhase 4NCT06373978· The Cleveland Clinic
2 U.S. sites in 2 states
- Group Music Therapy for Chronic Pain Management in Active Duty Service MembersRecruitingPhase 2NCT07755540· Henry M. Jackson Foundation for the Advancement of Military Medicine
1 U.S. site in 1 state
- RCT of a Weighted Blanket to Reduce Pain in Veterans With Chronic PainRecruitingNCT05963607· VA Office of Research and Development
2 U.S. sites in 1 state
- A Multicomponent Intervention for Patients With Lumbosacral Radiculopathy: Move-MORERecruitingNCT07125027· National University of Natural Medicine
1 U.S. site in 1 state
- Low Intensity Focused Ultrasound for Chronic Pain: High Resolution Targeting of The Human InsulaRecruitingNCT06906211· Washington D.C. Veterans Affairs Medical Center
1 U.S. site in 1 state
- Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus StudyRecruitingNCT07118722· Massachusetts General Hospital
1 U.S. site in 1 state
- A Pragmatic Trial of EAET for Veterans With Chronic PainRecruitingNCT07218757· University of California, Los Angeles
1 U.S. site in 1 state
- Prospective Assessment of Integrative Therapies for Neuromusculoskeletal Pain (PAIN)RecruitingNCT07094282· David Moss
1 U.S. site in 1 state
- Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic PainRecruitingNCT07639060· Yale University
1 U.S. site in 1 state
- From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human SubjectsRecruitingPhase 2NCT05661903· Massachusetts General Hospital
3 U.S. sites in 1 state
- Investigating the Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on the Brain in People With FibromyalgiaRecruitingNCT07260864· University of Rochester
1 U.S. site in 1 state
- VETERANS AFFAIRS AUGUSTARecruitingNCT07776600· Companion IQ, Inc
1 U.S. site in 1 state
- MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress DisorderRecruitingPhase 2NCT05790239· Stephen Robert Marder
2 U.S. sites in 1 state
- Video Intervention for Older Adults With Chronic PainRecruitingNCT07404618· Butler Hospital
1 U.S. site in 1 state
- Noninvasive Brain Stimulation for Treating Carpal Tunnel SyndromeRecruitingNCT04206215· Spaulding Rehabilitation Hospital
1 U.S. site in 1 state
Chronic pain studies by state
Frequently asked questions
- How many chronic pain clinical trials are recruiting?
- 232 chronic pain studies on ClinicalTrials.gov have at least one U.S. site and are open or about to open, out of 27,256 open U.S. studies overall.
- Which states have the most chronic pain trials?
- California (41), Massachusetts (32), New York (21) have the most studies with a site in the state.
- What does recruiting mean?
- Recruiting means the study is currently enrolling participants. Not yet recruiting means it has been registered but has not started enrolling. Enrolling by invitation means participants are selected by the study team rather than through open enrollment.
- How do I join a clinical trial?
- Read the full eligibility criteria and contact information on ClinicalTrials.gov, then talk with your doctor about whether a study may be right for you. The study team decides who can enroll.
Source: ClinicalTrials.gov, National Library of Medicine · Last updated 10/26/2026