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Migraine Clinical Trials
Studies with U.S. locations that are recruiting, about to recruit or enrolling by invitation
Study listings come from ClinicalTrials.gov, where sponsors register and update their own studies. A listing does not mean a study is safe or effective, and DatenUS does not recommend any study. Talk with your doctor before joining a clinical trial, and use ClinicalTrials.gov for contact details and full eligibility rules.
- Open studies
- 80
- With at least one U.S. site
- States with a site
- 48
- Most studies
- California
- 22 studies
Recently updated studies
50 of 80, recruiting studies first. Choose a state to see studies near you.
- Overlapping Pain Trajectory StudyRecruitingNCT05752396· Children's Hospital Medical Center, Cincinnati
1 U.S. site in 1 state
- Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison StudyRecruitingPhase 4NCT06972056· Mayo Clinic
37 U.S. sites in 23 states
- Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric SubjectsRecruitingPhase 3NCT05156398· Pfizer
56 U.S. sites in 24 states
- A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic MigraineRecruitingPhase 3NCT05164172· H. Lundbeck A/S
20 U.S. sites in 12 states
- A Study to Assess the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of MigraineRecruitingPhase 3NCT07816367· Kallyope Inc.
72 U.S. sites in 23 states
- A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 YearsRecruitingPhase 3NCT06810505· AbbVie
32 U.S. sites in 16 states
- Study Evaluating the Efficacy, Safety, and Tolerability of ASY202 (Dihydroergotamine Mesylate [DHE] Inhalation Powder Delivered Via a Multidose Dry Powder Inhaler) for the Acute Treatment of Migraine in Adult PatientsRecruitingPhase 2NCT07646613· Aspeya, Inc.
20 U.S. sites in 14 states
- RELAXaHEAD for Headache Patients (Phase III)RecruitingNCT06077838· NYU Langone Health
1 U.S. site in 1 state
- Migraine Headaches Elimination With Patent Foramen Ovale-Directed TherapyRecruitingPhase 3NCT07629635· Columbia University
1 U.S. site in 1 state
- NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar DisorderRecruitingNCT05669703· National Institute of Mental Health (NIMH)
1 U.S. site in 1 state
- Study of EVO756 in Adults With MigraineRecruitingPhase 2NCT07616128· Evommune, Inc.
33 U.S. sites in 16 states
- Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache TreatmentRecruitingPhase 2NCT07361549· Daniel A Tonetti, MD
1 U.S. site in 1 state
- A Study to Learn About the Study Medicine Called Zavegepant (PF-07930207) in Children With a History of MigraineRecruitingPhase 1NCT06995729· Pfizer
14 U.S. sites in 11 states
- MMA Embolization for Refractory Chronic MigraineRecruitingNCT06735833· Cerenovus, Part of DePuy Synthes Products, Inc.
8 U.S. sites in 6 states
- The Effect of Remote Electrical Neuromodulation (REN) on Conditioned Pain Modulation (CPM) in Migraine and FibromyalgiaRecruitingNCT07841509· Theranica
1 U.S. site in 1 state
- Randomized Study in Children and Adolescents With Migraine: Acute TreatmentRecruitingPhase 3NCT04649242· Pfizer
169 U.S. sites in 38 states
- Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of MigraineRecruitingPhase 3NCT04743141· Pfizer
115 U.S. sites in 33 states
- A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine HeadacheRecruitingPhase 4NCT06473597· Antonios Likourezos
1 U.S. site in 1 state
- EMBRACE-OBS: Single-Site Observational Registry of Patient-Reported Outcomes Following MMA Embolization for MigraineRecruitingNCT07652034· Cortex Neurovascular
1 U.S. site in 1 state
- Responding With Evidence and Access for Childhood HeadachesRecruitingNCT05889624· Children's Hospital Medical Center, Cincinnati
15 U.S. sites in 14 states
- Puberty, Testosterone, and Brain DevelopmentRecruitingNCT06670053· University of Colorado, Denver
1 U.S. site in 1 state
- Effectiveness and Tolerability of Zavegepant for Acute Migraine Treatment Among Those Using CGRP Targeting Preventive MedicationsRecruitingPhase 4NCT06401642· Mayo Clinic
1 U.S. site in 1 state
- Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)RecruitingPhase 3NCT05125302· AbbVie
125 U.S. sites in 36 states
- Objectively Diagnose and Monitor Treatment of Light SensitivityRecruitingNCT03694626· Randy Kardon
1 U.S. site in 1 state
- Bilateral Embolization of the Middle Meningeal Arteries for Refractory Chronic MigraineRecruitingNCT07223008· Johns Hopkins University
1 U.S. site in 1 state
- A Pivotal Clinical Study to Evaluate the MySalvia System for the Treatment of Resistant MigraineRecruitingNCT07719608· Salvia BioElectronics
3 U.S. sites in 3 states
- A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of MigraineRecruitingPhase 3NCT07645924· Kallyope Inc.
113 U.S. sites in 34 states
- Emgality for Migraine in BreastmilkRecruitingNCT06085144· University of California, San Francisco
1 U.S. site in 1 state
- Headache Ear Auditory Dizziness Sinus (HEADS) RegistryRecruitingNCT07754266· Association of Migraine Disorders
1 U.S. site in 1 state
- Migraine in AdolescentsRecruitingNCT05654012· Washington University School of Medicine
1 U.S. site in 1 state
- Mechanistic Studies of Psilocybin in Headache DisordersRecruitingEarly Phase 1NCT06464367· Yale University
1 U.S. site in 1 state
- Endometriosis and MigraineRecruitingNCT06785129· Washington University School of Medicine
1 U.S. site in 1 state
- Cocoa Extract for Migraine TrialRecruitingNCT06808230· Brigham and Women's Hospital
1 U.S. site in 1 state
- Chiropractic Care for Episodic MigraineRecruitingNCT06229834· Brigham and Women's Hospital
1 U.S. site in 1 state
- Treatment of Meniere's Disease With Migraine MedicationsRecruitingPhase 4NCT05582837· University of California, Irvine
1 U.S. site in 1 state
- BE WELL With Migraine: Brain Education and WELLness With MigraineRecruitingNCT05987592· Wake Forest University Health Sciences
3 U.S. sites in 3 states
- Determining the Utility of a Behavioral Intervention in Chronic MigraineRecruitingNCT05415020· Mayo Clinic
1 U.S. site in 1 state
- A Feasibility Trial of Virtual Reality Neurofeedback for Adolescents With MigraineRecruitingNCT07454798· Children's Mercy Hospital Kansas City
1 U.S. site in 1 state
- Bilateral Middle Meningeal Artery Lidocaine Infusion for Chronic Debilitating MigrainesRecruitingPhase 2NCT07061847· Northwell Health
1 U.S. site in 1 state
- A Study to Investigate the Safety and Efficacy of MEDI0618 Compared to Placebo in Adult Participants With Episodic MigraineRecruitingPhase 2NCT06602479· AbbVie
16 U.S. sites in 10 states
- Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?RecruitingEarly Phase 1NCT06016465· Texas Tech University Health Sciences Center, El Paso
1 U.S. site in 1 state
- Observational Study to Assess Maternal, Fetal and Infant Outcomes Following Exposure to RimegepantRecruitingNCT05046613· Pfizer
1 U.S. site in 1 state
- Light Exposure, Migraine Outcomes, and Sleep QualityRecruitingNCT07476053· Arizona State University
1 U.S. site in 1 state
- Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial PainRecruitingPhase 2NCT04930887· Stanford University
1 U.S. site in 1 state
- External Trigeminal Nerve Stimulation for Migraine Treatment in PregnancyRecruitingNCT06788977· Cefaly Technology
1 U.S. site in 1 state
- Mind Body Intervention for Chronic Migraine HeadachesRecruitingNCT06690060· Beth Israel Deaconess Medical Center
2 U.S. sites in 1 state
- Stimulation of External Carotid Artery CirculationRecruitingNCT07402954· The University of Texas Medical Branch, Galveston
1 U.S. site in 1 state
- Study to Assess the Real-World Effectiveness of Ubrogepant in Adult Participants When Treating During the Prodrome Phase of Migraine AttacksRecruitingNCT07310290· AbbVie
3 U.S. sites in 3 states
- Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation ResearchRecruitingNCT04806620· Brain Inflammation Collaborative
1 U.S. site in 1 state
- Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of MigrainesRecruitingPhase 3NCT06904287· Wake Forest University Health Sciences
1 U.S. site in 1 state
Migraine studies by state
Frequently asked questions
- How many migraine clinical trials are recruiting?
- 80 migraine studies on ClinicalTrials.gov have at least one U.S. site and are open or about to open, out of 27,256 open U.S. studies overall.
- Which states have the most migraine trials?
- California (22), Texas (20), New York (19) have the most studies with a site in the state.
- What does recruiting mean?
- Recruiting means the study is currently enrolling participants. Not yet recruiting means it has been registered but has not started enrolling. Enrolling by invitation means participants are selected by the study team rather than through open enrollment.
- How do I join a clinical trial?
- Read the full eligibility criteria and contact information on ClinicalTrials.gov, then talk with your doctor about whether a study may be right for you. The study team decides who can enroll.
Source: ClinicalTrials.gov, National Library of Medicine · Last updated 10/26/2026