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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

NCT05564377 on ClinicalTrials.gov

Study listings come from ClinicalTrials.gov, where sponsors register and update their own studies. A listing does not mean a study is safe or effective, and DatenUS does not recommend any study. Talk with your doctor before joining a clinical trial, and use ClinicalTrials.gov for contact details and full eligibility rules.

Status
Recruiting
Phase
Phase 2
Interventional
Planned enrollment
2,900
Participants, all sites
U.S. sites
480
In 44 states

Study details

Conditions
Advanced Malignant Solid Neoplasm, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Locally Advanced Malignant Solid Neoplasm, Malignant Female Reproductive System Neoplasm, Metastatic HER2-Negative Breast Carcinoma, Metastatic Malignant Solid Neoplasm, Recurrent Endometrial Carcinoma
Sponsor
National Cancer Institute (NCI) (National Institutes of Health)
Sex
All
Healthy volunteers
Not accepted
Start
04/07/2023
Primary completion (expected)
07/01/2030
Last updated by sponsor
10/26/2026

Full eligibility rules, contacts and site names: NCT05564377 on ClinicalTrials.gov

Where the study has sites

Cities with at least one listed U.S. site. Some sites may not be enrolling yet.

  • Alabama: Birmingham, Mobile
  • Alaska: Anchorage
  • Arizona: Goodyear, Kingman, Phoenix
  • Arkansas: Jonesboro
  • California: Carmichael (2), Los Angeles (2), Orange (2), Palo Alto (2), San Diego (2), Arroyo Grande, Dublin, Elk Grove, Encinitas, La Jolla, Martinez, Rocklin and 6 more
  • Colorado: Fort Collins (2), Aurora, Greeley, Loveland
  • Delaware: Newark (2)
  • Florida: Miami (2), Aventura, Coral Gables, Deerfield Beach, Fort Lauderdale, Gainesville, Jacksonville, North Miami, Plantation
  • Georgia: Newnan
  • Hawaii: Honolulu (7), ‘Aiea (2), ‘Ewa Beach
  • Idaho: Boise (2), Nampa (2), Caldwell, Coeur d'Alene, Fruitland, Meridian, Post Falls, Sandpoint, Twin Falls
  • Illinois: Chicago (6), Springfield (3), Decatur (2), Effingham (2), Glenview (2), Libertyville (2), Normal (2), Orland Park (2), Barrington, Bloomington, Canton, Carterville and 28 more
  • Indiana: Crown Point, Michigan City, Richmond, South Bend
  • Iowa: Des Moines (3), Cedar Rapids (2), Ankeny, Waukee
  • Kentucky: Lexington (2), Paducah
  • Louisiana: New Orleans (2), Metairie
  • Maine: Augusta, Brewer, Scarborough, South Portland
  • Maryland: Bethesda (2), Baltimore, Cumberland
  • Massachusetts: Boston (3), Springfield, Stoneham
  • Michigan: Flint (4), Kalamazoo (4), Brighton (3), Ann Arbor (2), Canton (2), Chelsea (2), Grand Rapids (2), Pontiac (2), Royal Oak (2), Saginaw (2), Saint Joseph (2), Ypsilanti (2) and 17 more
  • Minnesota: Edina (2), Saint Paul (2), Bemidji, Coon Rapids, Deer River, Duluth, Hibbing, Maple Grove, Maplewood, Minneapolis, Rochester, Saint Louis Park and 2 more
  • Mississippi: Columbus, Grenada, Gulfport, New Albany, Oxford, Southhaven
  • Missouri: St Louis (6), Springfield (2), Cape Girardeau, Chesterfield, City of Saint Peters, Creve Coeur, Farmington, Rolla, Saint Joseph, Sainte Genevieve, Sullivan
  • Montana: Anaconda, Billings, Bozeman, Great Falls, Kalispell, Missoula
  • Nebraska: Omaha (2), Bellevue
  • Nevada: Las Vegas (4), Reno
  • New Jersey: Flemington, Lakewood, Livingston, Long Branch, Middletown, New Brunswick, Pennington, Sewell, Somerville, Toms River
  • New Mexico: Albuquerque
  • New York: New York (3), The Bronx (3), Buffalo, Commack, Harrison, Mineola, Rochester, Syracuse
  • North Carolina: Greensboro (2), Asheboro, Burlington, Clinton, Durham, Goldsboro, High Point, Jacksonville, Raleigh, Reidsville, Winston-Salem
  • North Dakota: Fargo (2), Bismarck
  • Ohio: Columbus (7), Dayton (4), Cleveland (3), Cincinnati (2), Delaware (2), Dublin (2), Franklin (2), Kettering (2), Springfield (2), Toledo (2), Westerville (2), Athens and 24 more
  • Oklahoma: Oklahoma City
  • Oregon: Portland (3), Newberg, Ontario, Oregon City
  • Pennsylvania: Philadelphia (3), Pittsburgh (3), Allentown, Altoona, Bethlehem, Bryn Mawr, East Stroudsburg, Erie, Greensburg, Hazleton, Mechanicsburg, Media and 5 more
  • Rhode Island: Providence (2)
  • South Carolina: Greenville (6), Boiling Springs, Columbia, Easley, Greer, Seneca
  • South Dakota: Sioux Falls (2), Rapid City
  • Tennessee: Nashville (2), Collierville, Johnson City, Kingsport, Memphis
  • Texas: Houston (5), Abilene, Dallas, Lubbock, Nassau Bay, Sugar Land, Temple, The Woodlands
  • Virginia: Richmond (4), Bristol, Charlottesville, Fairfax, Falls Church, Roanoke, South Hill
  • Washington: Edmonds, Issaquah, Lacey, Renton, Seattle, Walla Walla, Yakima
  • West Virginia: Charleston, Huntington, Morgantown
  • Wisconsin: Green Bay (3), Milwaukee (3), Sheboygan (3), Appleton (2), Madison (2), Oshkosh (2), Ashland, Berlin, Burlington, Eau Claire, Germantown, Grafton and 24 more

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Frequently asked questions

What does recruiting mean?
Recruiting means the study is currently enrolling participants. Not yet recruiting means it has been registered but has not started enrolling. Enrolling by invitation means participants are selected by the study team rather than through open enrollment.
How do I join a clinical trial?
Read the full eligibility criteria and contact information on ClinicalTrials.gov, then talk with your doctor about whether a study may be right for you. The study team decides who can enroll.

Source: ClinicalTrials.gov, National Library of Medicine · Last updated 10/26/2026