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A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

NCT06136650 on ClinicalTrials.gov

Study listings come from ClinicalTrials.gov, where sponsors register and update their own studies. A listing does not mean a study is safe or effective, and DatenUS does not recommend any study. Talk with your doctor before joining a clinical trial, and use ClinicalTrials.gov for contact details and full eligibility rules.

Status
Recruiting
Phase
Phase 3
Interventional
Planned enrollment
1,314
Participants, all sites
U.S. sites
63
In 27 states

Study details

Conditions
Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostatic Neoplasms
Sponsor
Merck Sharp & Dohme LLC (Industry)
Ages
18 years and older
Sex
All
Healthy volunteers
Not accepted
Start
12/18/2023
Primary completion (expected)
05/10/2028
Last updated by sponsor
10/20/2026

Full eligibility rules, contacts and site names: NCT06136650 on ClinicalTrials.gov

Where the study has sites

Cities with at least one listed U.S. site. Some sites may not be enrolling yet.

  • Arizona: Tucson
  • California: Irvine, Los Angeles, Orange, Palo Alto, Redlands, Riverside, Sacramento, San Francisco, Vallejo
  • Colorado: Aurora, Highlands Ranch, Lakewood, Lone Tree
  • Connecticut: New Haven
  • District of Columbia: Washington D.C.
  • Florida: Fort Myers, Miami Beach, Pembroke Pines
  • Georgia: Atlanta
  • Illinois: Elmhurst, Naperville, Peoria
  • Indiana: Carmel
  • Kentucky: Lexington
  • Maryland: Baltimore (2), Towson
  • Michigan: Detroit, Grand Rapids
  • Minnesota: Marshall, Saint Louis Park, Saint Paul
  • Montana: Billings
  • Nebraska: Omaha
  • Nevada: Las Vegas (2)
  • New Jersey: New Brunswick
  • New York: Syracuse
  • Ohio: Cleveland, Gahanna, Zanesville
  • Pennsylvania: Bala-Cynwyd, Philadelphia
  • South Carolina: Charleston
  • South Dakota: Aberdeen, Mitchell, Pierre, Sioux Falls, Yankton
  • Tennessee: Germantown
  • Texas: Dallas (2), Austin, Houston
  • Virginia: Fairfax (2), Charlottesville, Richmond, Roanoke
  • Washington: Spokane, Vancouver
  • Wisconsin: Milwaukee

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Frequently asked questions

What does recruiting mean?
Recruiting means the study is currently enrolling participants. Not yet recruiting means it has been registered but has not started enrolling. Enrolling by invitation means participants are selected by the study team rather than through open enrollment.
How do I join a clinical trial?
Read the full eligibility criteria and contact information on ClinicalTrials.gov, then talk with your doctor about whether a study may be right for you. The study team decides who can enroll.

Source: ClinicalTrials.gov, National Library of Medicine · Last updated 10/20/2026