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Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

NCT06333899 on ClinicalTrials.gov

Study listings come from ClinicalTrials.gov, where sponsors register and update their own studies. A listing does not mean a study is safe or effective, and DatenUS does not recommend any study. Talk with your doctor before joining a clinical trial, and use ClinicalTrials.gov for contact details and full eligibility rules.

Status
Recruiting
Phase
Early Phase 1
Interventional
Planned enrollment
15
Participants, all sites
U.S. sites
10
In 9 states

Study details

Conditions
High Grade Glioma, Diffuse Intrinsic Pontine Glioma, Anaplastic Astrocytoma, Infant Type Hemispheric Glioma, Glioblastoma, Glioblastoma Multiforme, WHO Grade III Glioma, WHO Grade IV Glioma
Sponsor
Nationwide Children's Hospital (University, hospital or other organization)
Ages
1 to 21 years
Sex
All
Healthy volunteers
Accepted
Start
08/03/2025
Primary completion (expected)
07/01/2029
Last updated by sponsor
06/29/2026

Full eligibility rules, contacts and site names: NCT06333899 on ClinicalTrials.gov

Where the study has sites

Cities with at least one listed U.S. site. Some sites may not be enrolling yet.

  • Colorado: Aurora
  • District of Columbia: Washington D.C.
  • Illinois: Chicago
  • Massachusetts: Boston
  • North Carolina: Durham
  • Ohio: Cincinnati, Columbus
  • Pennsylvania: Philadelphia
  • Texas: Houston
  • Washington: Seattle

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Frequently asked questions

What does recruiting mean?
Recruiting means the study is currently enrolling participants. Not yet recruiting means it has been registered but has not started enrolling. Enrolling by invitation means participants are selected by the study team rather than through open enrollment.
How do I join a clinical trial?
Read the full eligibility criteria and contact information on ClinicalTrials.gov, then talk with your doctor about whether a study may be right for you. The study team decides who can enroll.

Source: ClinicalTrials.gov, National Library of Medicine · Last updated 06/29/2026