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A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)

NCT06742996 on ClinicalTrials.gov

Study listings come from ClinicalTrials.gov, where sponsors register and update their own studies. A listing does not mean a study is safe or effective, and DatenUS does not recommend any study. Talk with your doctor before joining a clinical trial, and use ClinicalTrials.gov for contact details and full eligibility rules.

Status
Recruiting
Phase
Phase 3
Interventional
Planned enrollment
300
Participants, all sites
U.S. sites
41
In 26 states

Study details

Conditions
Mantle Cell Lymphoma, B Cell Lymphoma
Sponsor
BeOne Medicines (Industry)
Ages
18 years and older
Sex
All
Healthy volunteers
Not accepted
Start
03/05/2025
Primary completion (expected)
08/31/2028
Last updated by sponsor
09/28/2026

Full eligibility rules, contacts and site names: NCT06742996 on ClinicalTrials.gov

Where the study has sites

Cities with at least one listed U.S. site. Some sites may not be enrolling yet.

  • Alabama: Birmingham
  • Arizona: Tucson
  • California: Fresno, Irvine
  • Connecticut: New Haven
  • Florida: Pembroke Pines, Weston
  • Illinois: Chicago (2)
  • Indiana: Fort Wayne
  • Iowa: Waukee
  • Louisiana: Baton Rouge
  • Maryland: Baltimore
  • Massachusetts: Boston
  • Michigan: Ann Arbor, Grand Rapids
  • Minnesota: Rochester
  • Mississippi: Hattiesburg
  • Missouri: St Louis
  • Nebraska: Grand Island, Omaha
  • New Jersey: Paramus
  • New York: New York
  • North Carolina: Charlotte, Durham, Winston-Salem
  • Ohio: Cleveland (2), Columbus (2)
  • Pennsylvania: Hershey, West Reading
  • Tennessee: Nashville (2)
  • Texas: Houston, Round Rock
  • Virginia: Charlottesville, Gainesville, Richmond
  • Washington: Vancouver
  • Wisconsin: Madison

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Frequently asked questions

What does recruiting mean?
Recruiting means the study is currently enrolling participants. Not yet recruiting means it has been registered but has not started enrolling. Enrolling by invitation means participants are selected by the study team rather than through open enrollment.
How do I join a clinical trial?
Read the full eligibility criteria and contact information on ClinicalTrials.gov, then talk with your doctor about whether a study may be right for you. The study team decides who can enroll.

Source: ClinicalTrials.gov, National Library of Medicine · Last updated 09/28/2026