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A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer

NCT07100106 on ClinicalTrials.gov

Study listings come from ClinicalTrials.gov, where sponsors register and update their own studies. A listing does not mean a study is safe or effective, and DatenUS does not recommend any study. Talk with your doctor before joining a clinical trial, and use ClinicalTrials.gov for contact details and full eligibility rules.

Status
Recruiting
Phase
Phase 1, Phase 2
Interventional
Planned enrollment
285
Participants, all sites
U.S. sites
33
In 21 states

Study details

Conditions
Breast Cancer
Sponsor
Genentech, Inc. (Industry)
Ages
18 years and older
Sex
All
Healthy volunteers
Not accepted
Start
10/07/2025
Primary completion (expected)
08/31/2028
Last updated by sponsor
10/26/2026

Full eligibility rules, contacts and site names: NCT07100106 on ClinicalTrials.gov

Where the study has sites

Cities with at least one listed U.S. site. Some sites may not be enrolling yet.

  • Alabama: Huntsville
  • Arizona: Tucson
  • California: Duarte, Irvine, La Jolla, San Diego, San Francisco
  • Colorado: Aurora
  • Florida: Miami, Tampa
  • Georgia: Atlanta
  • Illinois: Zion
  • Maine: Detroit
  • Maryland: Annapolis
  • Massachusetts: Boston
  • Missouri: St Louis
  • New Jersey: New Brunswick
  • New York: East Patchogue, The Bronx
  • North Carolina: Charlotte (2), Winston-Salem
  • Ohio: Canton, Cleveland
  • Oregon: Eugene
  • Pennsylvania: Hershey, Philadelphia, Pittsburgh
  • Tennessee: Mount Juliet, Nashville
  • Texas: Dallas
  • Utah: Salt Lake City
  • Virginia: Norfolk

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Frequently asked questions

What does recruiting mean?
Recruiting means the study is currently enrolling participants. Not yet recruiting means it has been registered but has not started enrolling. Enrolling by invitation means participants are selected by the study team rather than through open enrollment.
How do I join a clinical trial?
Read the full eligibility criteria and contact information on ClinicalTrials.gov, then talk with your doctor about whether a study may be right for you. The study team decides who can enroll.

Source: ClinicalTrials.gov, National Library of Medicine · Last updated 10/26/2026