Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Conditions

Advanced Endometrial Carcinoma, Recurrent Endometrial Carcinoma

Sponsor

National Cancer Institute (NCI) (National Institutes of Health)

Ages

18 years and older

Sex

Female only

Healthy volunteers

Not accepted

Start

01/27/2026

Primary completion (expected)

07/01/2028

Last updated by sponsor

10/23/2026

Full eligibility rules, contacts and site names: NCT07198074 on ClinicalTrials.gov

• Alabama: Birmingham
• Alaska: Anchorage
• Arizona: Tucson (2), Phoenix
• Arkansas: Fayetteville, Little Rock, Rogers, Springdale
• California: Sacramento (4), Los Angeles (3), Carmichael (2), Dublin, Elk Grove, Fremont, Fresno, Modesto, Oakland, Palo Alto, Rancho Mirage, Rocklin and 11 more
• Colorado: Colorado Springs (2), Fort Collins (2), Aurora, Greeley, Highlands Ranch, Loveland
• Connecticut: Hartford, Manchester, New Britain
• Delaware: Newark (2), Millville, Rehoboth Beach
• District of Columbia: Washington D.C.
• Florida: Sarasota (4), N. Venice, Venice
• Georgia: Atlanta (3), Augusta, Decatur
• Hawaii: Honolulu (6), ‘Aiea (2), ‘Ewa Beach
• Idaho: Coeur d'Alene, Post Falls, Sandpoint
• Illinois: Chicago (3), Springfield (3), Decatur (2), Normal (2), O'Fallon (2), Orland Park (2), Danville, DeKalb, Effingham, Evanston, Geneva, Glenview and 9 more
• Indiana: Crown Point, Goshen, Indianapolis, South Bend
• Iowa: Des Moines (5), Cedar Rapids (2), Ankeny, Carroll, Clive, Fort Dodge, Iowa City, Waukee
• Kentucky: Lexington (2)
• Louisiana: Metairie (2), Marrero, New Orleans
• Maine: Brewer, Scarborough
• Maryland: Baltimore (2)
• Massachusetts: Boston
• Michigan: Flint (3), Kalamazoo (3), Brighton (2), Grand Rapids (2), Saint Joseph (2), Ann Arbor, Battle Creek, Canton, Chelsea, Detroit, Escanaba, Farmington Hills and 11 more
• Minnesota: Edina (2), Minneapolis (2), Saint Paul (2), Brainerd, Coon Rapids, Deer River, Duluth, Hibbing, Saint Louis Park, Sandstone, Virginia, Woodbury
• Missouri: Springfield (2), Columbia, St Louis
• Montana: Billings (3), Anaconda, Bozeman, Great Falls, Kalispell, Missoula
• Nebraska: Omaha (3), Bellevue, Kearney
• Nevada: Las Vegas
• New Jersey: Basking Ridge, Livingston, Middletown, Montvale, New Brunswick, Newark, Paramus, Ridgewood, Sewell
• New Mexico: Albuquerque
• New York: New York (6), The Bronx (3), Bay Shore, Commack, Flushing, Greenlawn, Harrison, Lake Success, Rego Park, Rochester, Sleepy Hollow, Staten Island and 4 more
• North Carolina: Chapel Hill, Clinton, Durham, Goldsboro, Jacksonville, Raleigh
• North Dakota: Fargo
• Ohio: Columbus (5), Delaware (2), Dublin (2), Athens, Beachwood, Canton, Chardon, Cleveland, Mansfield, Marion, Mentor, Parma and 4 more
• Oklahoma: Oklahoma City
• Oregon: Portland (3), Tualatin
• Pennsylvania: Philadelphia (2), Pittsburgh (2), Erie, Greensburg, Hershey, Mechanicsburg, Washington, Willow Grove
• Rhode Island: Providence (2)
• Tennessee: Nashville (2), Franklin
• Utah: Salt Lake City (2), South Jordan
• Virginia: Charlottesville, Richmond
• Washington: Edmonds, Issaquah, Seattle, Vancouver
• West Virginia: Bridgeport, Charleston, Martinsburg, Morgantown, Parkersburg
• Wisconsin: Green Bay (2), Sheboygan (2), Ashland, La Crosse, Milwaukee, Oconto Falls, Spooner, Sturgeon Bay, Superior

• Cancer (all types)

Frequently asked questions

What does recruiting mean?

Recruiting means the study is currently enrolling participants. Not yet recruiting means it has been registered but has not started enrolling. Enrolling by invitation means participants are selected by the study team rather than through open enrollment.

How do I join a clinical trial?

Read the full eligibility criteria and contact information on ClinicalTrials.gov, then talk with your doctor about whether a study may be right for you. The study team decides who can enroll.