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Heart failure Clinical Trials
Studies with U.S. locations that are recruiting, about to recruit or enrolling by invitation
Study listings come from ClinicalTrials.gov, where sponsors register and update their own studies. A listing does not mean a study is safe or effective, and DatenUS does not recommend any study. Talk with your doctor before joining a clinical trial, and use ClinicalTrials.gov for contact details and full eligibility rules.
- Open studies
- 298
- With at least one U.S. site
- States with a site
- 51
- Most studies
- California
- 87 studies
Recently updated studies
50 of 298, recruiting studies first. Choose a state to see studies near you.
- Changes in Skeletal Muscle Thickness in Patients With Acute Heart FailureRecruitingNCT06253104· Tufts Medical Center
1 U.S. site in 1 state
- Assessment of CCM in HF With Higher Ejection FractionRecruitingNCT05064709· Impulse Dynamics
67 U.S. sites in 28 states
- Synchronized Diaphragmatic Stimulation in Symptomatic Heart FailureRecruitingNCT06552637· VisCardia Inc.
4 U.S. sites in 4 states
- A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)RecruitingPhase 2NCT06991257· Pfizer
30 U.S. sites in 8 states
- Mobile Health Intervention to Increase Activity in Heart Failure StudyRecruitingNCT07750262· University of Michigan
1 U.S. site in 1 state
- Rural Community Peer Partnerships for Improving Methamphetamine-Associated Heart Failure Screening and EngagementRecruitingNCT06461962· Oregon Health and Science University
1 U.S. site in 1 state
- Sensor-based Congestion ALert for Events in Peritoneal Dialysis (SCALE-PD)RecruitingNCT07059962· Bodyport Inc.
4 U.S. sites in 4 states
- Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft TissuesRecruitingNCT01757730· Arunark Kolipaka
1 U.S. site in 1 state
- Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With DapagliflozinRecruitingPhase 3NCT06677060· AstraZeneca
218 U.S. sites in 41 states
- Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart FailureRecruitingNCT07232030· CVRx, Inc.
20 U.S. sites in 14 states
- Fluid Guided Heart Failure Treatment at the Cleveland ClinicRecruitingNCT07205120· Bodyport Inc.
1 U.S. site in 1 state
- A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart DiseaseRecruitingNCT07214376· Pulnovo Medical, Inc.
14 U.S. sites in 10 states
- Advancing Clinical Heart Failure Outcomes Leveraging Defibrillation Lead Implant System for Left Bundle Branch Area PacingRecruitingNCT07526896· Medtronic Cardiac Rhythm and Heart Failure
1 U.S. site in 1 state
- PrEcision Pacing in HFpEF: the PEP-HFpEF TrialRecruitingNCT07864558· Tufts Medical Center
1 U.S. site in 1 state
- The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)RecruitingNCT05427370· Sunnybrook Health Sciences Centre
6 U.S. sites in 6 states
- Ketogenic Diet vs Mixed Diet in Patients With Heart FailureRecruitingNCT06081543· Ohio State University
1 U.S. site in 1 state
- The HEARTFELT StudyRecruitingNCT06222099· Heartfelt Technologies
3 U.S. sites in 3 states
- The WiSE®-UP Study (The WiSE System Utilization & Performance Study)RecruitingNCT07098858· EBR Systems, Inc.
12 U.S. sites in 11 states
- NORM-HF Pivotal StudyRecruitingNCT07574593· Foundry Innovation & Research 1, Limited (FIRE1)
25 U.S. sites in 14 states
- A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic DysfunctionRecruitingPhase 3NCT07188805· Bayer
22 U.S. sites in 14 states
- A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic DysfunctionRecruitingPhase 3NCT07192952· Bayer
22 U.S. sites in 14 states
- Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart FailureRecruitingNCT06364644· Johns Hopkins University
2 U.S. sites in 1 state
- A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart FailureRecruitingPhase 3NCT06424288· Boehringer Ingelheim
94 U.S. sites in 30 states
- A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the HeartRecruitingPhase 3NCT06935370· Boehringer Ingelheim
89 U.S. sites in 21 states
- Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney FunctionRecruitingPhase 3NCT06307652· AstraZeneca
166 U.S. sites in 37 states
- Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection FractionRecruitingPhase 3NCT06736574· Cytokinetics
88 U.S. sites in 33 states
- INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac RecoveryRecruitingNCT06965504· Abiomed Inc.
17 U.S. sites in 11 states
- Central Apnea in Heart Failure: Physiological Mechanisms to Inform TreatmentRecruitingPhase 4NCT07210606· VA Office of Research and Development
1 U.S. site in 1 state
- A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)RecruitingPhase 2NCT07795814· Edgewise Therapeutics, Inc.
28 U.S. sites in 21 states
- Technical Development of Cardiovascular Magnetic Resonance ImagingRecruitingNCT04927429· National Heart, Lung, and Blood Institute (NHLBI)
2 U.S. sites in 2 states
- Intestinal Microbiota Transplantation in Patients With Chronic Heart FailureRecruitingPhase 1NCT07490054· Melana Yuzefpolskaya, MD
1 U.S. site in 1 state
- CSP #2025 - Geriatric OUt-of-hospital Randomized MEal Trial in Heart Failure: Veterans Affairs (GOURMET-VA)RecruitingNCT05996328· VA Office of Research and Development
21 U.S. sites in 18 states
- Home-Based Exercise Program Using Mobile Technology After Left Ventricular Assist Device ImplantationRecruitingNCT06291922· University of Pennsylvania
4 U.S. sites in 4 states
- Peripheral Venous Pressure (PVP) TrialRecruitingNCT07400042· Wake Forest University Health Sciences
1 U.S. site in 1 state
- Alleviant ALLAY-HFrEF StudyRecruitingNCT06812533· Alleviant Medical, Inc.
40 U.S. sites in 19 states
- Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) ImagingRecruitingNCT03581318· National Heart, Lung, and Blood Institute (NHLBI)
1 U.S. site in 1 state
- A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular HypertrophyRecruitingPhase 2NCT06979362· Novo Nordisk A/S
29 U.S. sites in 16 states
- Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart FailureRecruitingNCT07069738· Boston Scientific Corporation
42 U.S. sites in 24 states
- Early Feasibility Study - Edwards APTURE Transcatheter Shunt SystemRecruitingNCT03523416· Edwards Lifesciences
19 U.S. sites in 15 states
- ELEVATE-HFpEF Clinical StudyRecruitingNCT06678841· Medtronic Cardiac Rhythm and Heart Failure
26 U.S. sites in 22 states
- A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated CardiomyopathyRecruitingPhase 1NCT07137338· Rocket Pharmaceuticals Inc.
3 U.S. sites in 3 states
- A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection FractionRecruitingPhase 1NCT07465653· Novartis Pharmaceuticals
5 U.S. sites in 1 state
- Infusing Needed Iron to Target Insufficiency in Adults Treated for Evidence of Heart FailureRecruitingNCT07467668· Kaiser Permanente
1 U.S. site in 1 state
- HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment TargetsRecruitingNCT05873634· Northwestern University
6 U.S. sites in 6 states
- Myocardial Mechanisms in Heart Failure With Preserved Ejection FractionRecruitingNCT06517186· Northwestern University
6 U.S. sites in 6 states
- NT-ProBNP-based Heart Failure Screening and Prevention Trial in Patients With Type 2 Diabetes: STRONG-DM StudyRecruitingNCT06593327· University of Texas Southwestern Medical Center
3 U.S. sites in 1 state
- BiVACOR® Total Artificial Heart Early Feasibility StudyRecruitingNCT06174103· BiVACOR Inc.
4 U.S. sites in 4 states
- A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEFRecruitingPhase 3NCT07761117· AstraZeneca
120 U.S. sites in 34 states
- : Vascular Function in Health and DiseaseRecruitingPhase 1NCT02966665· D. Walter Wray
1 U.S. site in 1 state
- Evaluation of Liver Stiffness Performance, by FibroScan®, to Detect Elevated Central Venous Pressure (CVP)RecruitingNCT07222813· Echosens
4 U.S. sites in 4 states
Heart failure studies by state
Frequently asked questions
- How many heart failure clinical trials are recruiting?
- 298 heart failure studies on ClinicalTrials.gov have at least one U.S. site and are open or about to open, out of 27,256 open U.S. studies overall.
- Which states have the most heart failure trials?
- California (87), Texas (78), New York (70) have the most studies with a site in the state.
- What does recruiting mean?
- Recruiting means the study is currently enrolling participants. Not yet recruiting means it has been registered but has not started enrolling. Enrolling by invitation means participants are selected by the study team rather than through open enrollment.
- How do I join a clinical trial?
- Read the full eligibility criteria and contact information on ClinicalTrials.gov, then talk with your doctor about whether a study may be right for you. The study team decides who can enroll.
Source: ClinicalTrials.gov, National Library of Medicine · Last updated 10/26/2026