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migraine formula

acetaminophen, aspirin, caffeine · migraine formula is a central nervous system stimulant (over-the-counter) containing acetaminophen, aspirin, caffeine, made by 4 manufacturers.

Type
Over the counter
Drug class
Central Nervous System Stimulant
Route
Oral
Manufacturers
4

• treats migraine

Drug facts

Generic name
acetaminophen, aspirin, caffeine
Active ingredients
Acetaminophen, Aspirin, Caffeine
How it works
Cyclooxygenase Inhibitors
Dosage forms
Tablet, film coated
Label holder
HyVee Inc
FDA application
ANDA075794
Label updated
05/08/2026

Active ingredients

(in each caplet) Acetaminophen 250 mg Aspirin 250 mg (NSAID*) Caffeine 65 mg *nonsteroidal anti-inflammatory drug

Purpose

Pain reliever Pain reliever aid

Uses

  • Treats migraine

Directions

  • Do not use more than directed
  • Adults: take 2 caplets with a glass of water
  • If symptoms persist or worsen, ask your doctor
  • Do not take more than 2 caplets in 24 hours, unless directed by a doctor
  • Under 18 years of age: ask a doctor

Warnings

Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:

  • Skin reddening
  • Blisters
  • Rash If a skin reaction occurs, stop use and seek medical help right away. Allergy alert: Aspirin may cause a severe allergic reaction which may include:
  • Hives
  • Facial swelling
  • Asthma (wheezing)
  • Shock Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
  • More than 2 caplets in 24 hours, which is the maximum daily amount
  • With other drugs containing acetaminophen
  • 3 or more alcoholic drinks every day while using this product Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
  • Are age 60 or older
  • Have had stomach ulcers or bleeding problems
  • Take a blood thinning (anticoagulant) or steroid drug
  • Take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
  • Have 3 or more alcoholic drinks every day while using this product
  • Take more or for a longer time than directed Medication overuse headache warning: Headaches may worsen if this is used for 10 or more days per month. Caffeine warning: The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat. Do not use
  • If you have ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer
  • With any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. Ask a doctor before use if
  • You have never had migraines diagnosed by a health professional
  • You have a headache that is different from your usual migraines
  • You have the worst headache of your life
  • You have fever and stiff neck
  • You have headaches beginning after or caused by head injury, exertion, coughing or bending
  • You experienced your first headache after the age of 50
  • You have daily headaches
  • You have a migraine so severe as to require bed rest
  • You have liver disease
  • Stomach bleeding warning applies to you
  • You have a history of stomach problems, such as heartburn
  • You have high blood pressure, heart disease, liver cirrhosis, or kidney disease
  • You are taking a diuretic
  • You have asthma
  • You have problems or serious side effects from taking pain relievers or fever reducers
  • You have vomiting with your migraine headache Ask a doctor or pharmacist before use if you are
  • Taking a prescription drug for:
  • Diabetes
  • Gout
  • Arthritis
  • Under a doctor’s care for any serious condition
  • Taking any other drug
  • Taking any other product that contains aspirin, acetaminophen, or any other pain reliever/fever reducer Stop use and ask a doctor if
  • An allergic reaction occurs. Seek medical help right away.
  • You experience any of the following signs of stomach bleeding
  • Feel faint
  • Vomit blood
  • Have bloody or black stools
  • Have stomach pain that does not get better
  • Your migraine is not relieved or worsens after first dose
  • New or unexpected symptoms occur
  • Ringing in the ears or loss of hearing occurs If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222) Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

Do not use

  • If you have ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer
  • With any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.

Ask a doctor before use

If

  • You have never had migraines diagnosed by a health professional
  • You have a headache that is different from your usual migraines
  • You have the worst headache of your life
  • You have fever and stiff neck
  • You have headaches beginning after or caused by head injury, exertion, coughing or bending
  • You experienced your first headache after the age of 50
  • You have daily headaches
  • You have a migraine so severe as to require bed rest
  • You have liver disease
  • Stomach bleeding warning applies to you
  • You have a history of stomach problems, such as heartburn
  • You have high blood pressure, heart disease, liver cirrhosis, or kidney disease
  • You are taking a diuretic
  • You have asthma
  • You have problems or serious side effects from taking pain relievers or fever reducers
  • You have vomiting with your migraine headache

Ask a doctor or pharmacist before use

  • Taking a prescription drug for:
  • Diabetes
  • Gout
  • Arthritis
  • Under a doctor’s care for any serious condition
  • Taking any other drug
  • Taking any other product that contains aspirin, acetaminophen, or any other pain reliever/fever reducer

Stop use and ask a doctor

  • An allergic reaction occurs. Seek medical help right away.
  • You experience any of the following signs of stomach bleeding
  • Feel faint
  • Vomit blood
  • Have bloody or black stools
  • Have stomach pain that does not get better
  • Your migraine is not relieved or worsens after first dose
  • New or unexpected symptoms occur
  • Ringing in the ears or loss of hearing occurs

Pregnancy or breastfeeding

Ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Keep out of reach of children

In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222) Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

Other information

  • Store at 20°-25°C (68°-77°F)
  • Close cap tightly after use
  • Read all product information before using. Keep this box for important information.

Inactive ingredients

Carnauba wax, crospovidone, FD&C blue #1 aluminum lake, hypromellose, microcrystalline cellulose, povidone, pregelatinized starch, propylene glycol, saccharin sodium, stearic acid, titanium dioxide

Questions?

1-800-289-8343

Forms and strengths

From the FDA NDC Directory · 4 product codes

Dosage formStrengthRouteNDCs
Tablet, film coated250 mg / 250 mg / 65 mgoral4

Manufacturers and labels

4 FDA labels

  • HyVee IncShown hereANDA075794 · Label 05/08/2026 · NDC 42507-374Full label
  • H E BANDA075794 · Label 09/19/2025 · NDC 37808-374Full label
  • Meijer Distribution IncANDA075794 · Label 06/16/2025 · NDC 41250-374Full label
  • Meijer, Inc.ANDA075794 · Label 04/08/2026 · NDC 79481-0211Full label

Related recalls

FDA drug recalls that name this drug or its active ingredient

All drug recalls

migraine formula: common questions

What is migraine formula used for?
• treats migraine
Is migraine formula a prescription drug?
No. migraine formula is sold over the counter (OTC) without a prescription.
Are there other products with the same active ingredient as migraine formula?
Yes. Other FDA-listed products with the same active ingredients include Headache Relief Extra Strength, Headache Relief, Acetaminophen, Aspirin and Caffeine, Headache Relief Extra Strength.
Who makes migraine formula?
4 manufacturers list migraine formula with the FDA, including HyVee Inc, H E B, Meijer Distribution Inc.

Source: U.S. Food and Drug Administration, openFDA drug label (SPL) and NDC Directory · Last updated 05/08/2026 · Label text is shown as published by the manufacturer. Not medical advice