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Nasal Four

phenylephrine hydrochloride · Nasal Four is an over-the-counter drug containing phenylephrine hydrochloride, made by HyVee Inc.

Type
Over the counter
Drug class
Not classified
Route
Nasal
Manufacturers
1

• temporarily relieves nasal congestion due to: • common cold • hay fever • upper respiratory allergies

Drug facts

Generic name
phenylephrine hydrochloride
Active ingredients
Phenylephrine Hydrochloride
Dosage forms
Spray
Label holder
HyVee Inc
FDA application
M012
Label updated
04/01/2026

Active ingredients

Phenylephrine hydrochloride 1%

Purpose

Nasal decongestant

Uses

  • Temporarily relieves nasal congestion due to:
  • Common cold
  • Hay fever
  • Upper respiratory allergies

Directions

  • Adults and children 12 years and over: 2 or 3 sprays in each nostril not more often than every 4 hours
  • Children under 12 years: ask a doctor
  • Use instructions: with head in a normal, upright position, put atomizer tip into nostril. Squeeze bottle with firm, quick pressure while inhaling. Wipe nozzle clean after each use.

Ask a doctor before use

  • Heart disease
  • Diabetes
  • Thyroid disease
  • High blood pressure
  • Trouble urinating due to an enlarged prostate gland

When using this product

  • Do not use more than directed
  • Do not use for more than 3 days. Frequent or prolonged use may cause nasal congestion to come back or get worse.
  • Use only as directed
  • Temporary discomfort such as burning, stinging, sneezing or an increase in nasal discharge may occur
  • Use of this container by more than one person may spread infection

Stop use and ask a doctor

Symptoms persist

Pregnancy or breastfeeding

Ask a health professional before use.

Keep out of reach of children

If swallowed, get medical help or contact a Poison Control Center right away. (1-800-222-1222)

Other information

  • Store at 20°-25°C (68°-77°F)

Inactive ingredients

Benzalkonium chloride solution, benzyl alcohol, boric acid, purified water, sodium borate

Questions?

1-800-289-8343

Forms and strengths

From the FDA NDC Directory · 1 product codes

Dosage formStrengthRouteNDCs
Spray1 g/100mLnasal1

Side effect reports to FDA

FDA Adverse Event Reporting System (FAERS), 3,734 reports that list phenylephrine hydrochloride, data through 07/30/2026

Anyone can report a problem to FDA, and a report does not mean the drug caused the problem. Reports can be duplicated or incomplete, and counts depend on how widely a drug is used. Do not stop or change a medicine because of this list. Talk to your doctor or pharmacist.

Most often reported reactions

  • Off label use1,329
  • Pemphigus1,039
  • Joint swelling1,005
  • Pain981
  • Drug ineffective970
  • Rheumatoid arthritis960
  • Infusion related reaction953
  • Systemic lupus erythematosus948
  • Pericarditis944
  • Maternal exposure during pregnancy940

To report a side effect, use FDA MedWatch.

Manufacturers and labels

1 FDA label

  • HyVee IncShown hereM012 · Label 04/01/2026 · NDC 42507-648Full label

Related recalls

FDA drug recalls that name this drug or its active ingredient

All drug recalls

Nasal Four: common questions

What is Nasal Four used for?
• temporarily relieves nasal congestion due to: • common cold • hay fever • upper respiratory allergies
Is Nasal Four a prescription drug?
No. Nasal Four is sold over the counter (OTC) without a prescription.
Are there other products with the same active ingredient as Nasal Four?
Yes. Other FDA-listed products with the same active ingredients include Nasal, Nasal Decongestant PE, Nasal Decongestant PE Maximum Strength, Equate Nasal.
Who makes Nasal Four?
HyVee Inc lists Nasal Four with the FDA.

Source: U.S. Food and Drug Administration, openFDA drug label (SPL) and NDC Directory · Last updated 04/01/2026 · Label text is shown as published by the manufacturer. Not medical advice