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Defiance, MO
Census-designated place in St. Charles County, Missouri.
Population
63
Land area
1sq mi
People per sq mi
62
ZIP codes
0
Defiance and its ZIP codes
Defiance at a glance
- Defiance is 31% less dense than Missouri as a whole.
Local data for Defiance, MO
Counts from official public data
Economy and federal money
Jobs, pay, income and spending are for St. Charles County. PPP loans are for Defiance.
Unemployment rate
3.3%
Aug 2026, -0.3 pts in a year
Average annual pay
$62,680
162,655 jobs, 2025
Income per person
$71,954
BEA, 2024
Federal spending
$2.5B
FY 2026, $6,244 per person
Environment and hazard risk
Defiance, MO, from FEMA, NOAA and EPA
Natural hazard risk
Relatively Moderate
Top: strong wind
Storm events since 1996
865
Countywide, mostly thunderstorm wind
Flood insurance policies
1,076
0.8% of homes, county
July high / Jan low
88° / 21°F
44.4 inches of rain a year
Health statistics
Share of adults in Defiance, MO, CDC PLACES estimates
Obesity
36.3%
U.S. 33.3% +3.0 pts
Diabetes
12.3%
U.S. 12.1% about the same
Smoking
12.5%
U.S. 12.8% about the same
Uninsured (18-64)
4.5%
U.S. 11.1% -6.6 pts
Cities near Defiance
| Name | Distance | Land area (sq mi) |
|---|---|---|
| AugustaTown | 7.2 mi | 0.9 |
| Weldon Spring HeightsTown | 7.3 mi | 0.1 |
| WildwoodCity | 7.4 mi | 66.7 |
| New MelleCity | 7.8 mi | 1.7 |
| Weldon SpringCity | 8.9 mi | 7.6 |
| Gray SummitCensus-designated place | 9.8 mi | 7.7 |
| Dardenne PrairieCity | 9.9 mi | 5.3 |
| Lake St. LouisCity | 10 mi | 8.5 |
| Clarkson ValleyCity | 10 mi | 2.7 |
| CottlevilleCity | 10 mi | 4.7 |
| PacificCity | 11 mi | 6.9 |
| ChesterfieldCity | 11 mi | 31.8 |
| O'FallonCity | 11 mi | 30.6 |
| EllisvilleCity | 11 mi | 4.4 |
| EurekaCity | 12 mi | 11.2 |
| St. PetersCity | 13 mi | 22.5 |
Frequently asked questions
- What county is Defiance, MO in?
- Defiance is in St. Charles County, Missouri.
- What is the population of Defiance, MO?
- About 63 people live in Defiance, based on American Community Survey 5-year estimates.
- What cities are near Defiance?
- Nearby places include Augusta (7.2 mi), Weldon Spring Heights (7.3 mi), Wildwood (7.4 mi), New Melle (7.8 mi), Weldon Spring (8.9 mi).
Source: U.S. Census Bureau (TIGER/Line boundaries, American Community Survey) · Data as of 12/31/2023