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Madison County, MO
6 cities and towns and 2 ZIP codes in Madison County, Missouri.
Population
12,729
Land area
494sq mi
People per sq mi
26
ZIP codes
2
Cities and towns in Madison County
Madison County at a glance
- Madison County is 71% less dense than Missouri as a whole.
- Households here earn a median of $54,434 a year, 23% less than the Missouri figure of $70,702.
- A typical owner-occupied home is valued at $159,000 (31% below Missouri) and median rent is $808 a month.
- The biggest population centers are Fredericktown (4,507), Junction City (372) and Mine La Motte (370).
Local data for Madison County, MO
Counts from official public data
Housing and community stats
Madison County, MO, American Community Survey 2020-2024
Median household income
$54,434
Poverty rate
13.2%
Median home value
$159,000
Prices -0.6% in a year
Median rent
$808/mo
Homeownership
73.7%
Bachelor's or higher
16.3%
Median age
41.1
Average commute
23.9 min
Largest reported origins and ancestries: German Americans (2,129), Irish Americans (1,465), French Americans (361).
Economy and federal money
Jobs, income, federal spending and pandemic loans
Unemployment rate
3.6%
Sep 2026, -0.3 pts in a year
Average annual pay
$42,892
3,552 jobs, 2025
Income per person
$46,657
BEA, 2024
Federal spending
$89.9M
FY 2026, $7,122 per person
PPP loans
$22.7M
528 loans, 3,393 jobs reported
Campaign donations
$28.2K
Itemized, 2026 cycle
How people get to work
Madison County, MO, workers 16 and older. American Community Survey 5-year estimates
- Drove alone74.4%
- Carpooled9.7%
- Public transit0.7%
- Walked1.9%
- Bicycle0.2%
- Taxi, ride-hailing, motorcycle or other2.0%
- Worked from home11.0%
Average one-way commute: 23.9 minutes for people who do not work from home.
Environment and hazard risk
Madison County, MO, from FEMA, NOAA and EPA
Natural hazard risk
Relatively Low
Top: heat wave
Storm events since 1996
255
Most often thunderstorm wind
Flood insurance policies
25
0.4% of homes, county
July high / Jan low
88° / 21°F
46.3 inches of rain a year
Hazards, floods and storm historyCheck a flood zone4 historic places
Health statistics
Share of adults in Madison County, MO, CDC PLACES estimates
Obesity
37.7%
U.S. 33.3% +4.4 pts
Diabetes
13.2%
U.S. 12.1% +1.1 pts
Smoking
19.3%
U.S. 12.8% +6.5 pts
Uninsured (18-64)
9.6%
U.S. 11.1% -1.5 pts
Cities, towns and ZIP codes in Madison County
Population shown
Frequently asked questions
- What is the largest city in Madison County, MO?
- Fredericktown is the largest city or town in Madison County, with about 4,507 residents.
- How many ZIP codes are in Madison County?
- Madison County includes 2 ZIP Code Tabulation Areas, including 63645, 63655.
- What is the population of Madison County, MO?
- About 12,729 people live in Madison County, based on American Community Survey 5-year estimates.
- What counties border Madison County?
- Madison County borders St. Francois County, Perry County, Wayne County, Bollinger County, Iron County.
Source: U.S. Census Bureau (TIGER/Line boundaries, American Community Survey) · Data as of 12/31/2023