What is the largest city in Scott County, MO?

Sikeston is the largest city or town in Scott County, with about 16,320 residents.

How many ZIP codes are in Scott County?

Scott County includes 11 ZIP Code Tabulation Areas, including 63736, 63740, 63742, 63758, 63767.

What is the population of Scott County, MO?

About 37,933 people live in Scott County, based on American Community Survey 5-year estimates.

What counties border Scott County?

Scott County borders Cape Girardeau County, Stoddard County, New Madrid County, Mississippi County, Alexander County, IL.

Scott County, MO: Cities, ZIP Codes & Local Data

Population

37,933

Land area

420sq mi

People per sq mi

90

ZIP codes

11

Scott County at a glance

The median household income is $62,782, 11% below the Missouri median of $70,702.
A typical owner-occupied home is valued at $154,400 (33% below Missouri) and median rent is $873 a month.
Its largest cities are Sikeston (16,320), Scott City (4,371) and Chaffee (3,026).

Local data for Scott County, MO

Counts from official public data

Housing and community stats

Scott County, MO, American Community Survey 2020-2024

Full profile

Median household income

$62,782

Poverty rate

12.8%

Median home value

$154,400

Prices +2.2% in a year

Median rent

$873/mo

Homeownership

71.1%

Bachelor's or higher

22.1%

Median age

39.7

Average commute

18.6 min

Largest reported origins and ancestries: German Americans (7,580), Irish Americans (3,745), Mexican Americans (862).

Home values and rents Income, education and commute

Economy and federal money

Jobs, income, federal spending and pandemic loans

Details

Unemployment rate

4.0%

Aug 2026, -0.4 pts in a year

Average annual pay

$51,776

16,184 jobs, 2025

Income per person

$54,217

BEA, 2024

Federal spending

$281M

FY 2026, $7,375 per person

PPP loans

$107M

1,945 loans, 13,303 jobs reported

Campaign donations

$211K

Itemized, 2026 cycle

Economy Federal spending PPP loans

How people get to work

Scott County, MO, workers 16 and older. American Community Survey 5-year estimates

Drove alone83.1%
Carpooled10.2%
Public transit0.0%
Walked0.8%
Bicycle0.4%
Taxi, ride-hailing, motorcycle or other1.1%
Worked from home4.4%

Average one-way commute: 18.6 minutes for people who do not work from home.

Environment and hazard risk

Scott County, MO, from FEMA, NOAA and EPA

Full report

Natural hazard risk

Relatively Low

Top: earthquake

Storm events since 1996

888

Most often thunderstorm wind

Flood insurance policies

665

4.1% of homes, county

July high / Jan low

89° / 26°F

47.9 inches of rain a year

Hazards, floods and storm history Check a flood zone 6 historic places

Health statistics

Share of adults in Scott County, MO, CDC PLACES estimates

All 40 measures

Obesity

38.1%

U.S. 33.3% +4.8 pts

Diabetes

13.4%

U.S. 12.1% +1.3 pts

Smoking

19.2%

U.S. 12.8% +6.4 pts

Uninsured (18-64)

9.8%

U.S. 11.1% -1.3 pts

Cities, towns and ZIP codes in Scott County

Population shown

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Frequently asked questions

What is the largest city in Scott County, MO?: Sikeston is the largest city or town in Scott County, with about 16,320 residents.
How many ZIP codes are in Scott County?: Scott County includes 11 ZIP Code Tabulation Areas, including 63736, 63740, 63742, 63758, 63767.
What is the population of Scott County, MO?: About 37,933 people live in Scott County, based on American Community Survey 5-year estimates.
What counties border Scott County?: Scott County borders Cape Girardeau County, Stoddard County, New Madrid County, Mississippi County, Alexander County, IL.